Name:
Seutter von Loetzen, Christian, Dr.
Date of Birth:
March 24, 1985
Address:
Universität Bayreuth; Dept. of Biopolymers
Universitätsstraße 30, 95447 Bayreuth
Phone: +49 921 55-3869
 
Email: Christian.Seutter@uni-bayreuth.de

Current Position
from 2011 Scientific staff member, Dept. of Biopolymers, U Bayreuth

Education
2009 Bachelor of Science in Biochemistry, Universität Bayreuth: Prof. Dobbek, Department of Bioanorganic Chemistry,
Topic: Cloning, expression, purification and characterization of the [Fe-Fe] maturation protein HydF from Carboxydothermus hydrogenoformans
2011 Master of Science in Biochemistry, Universität Bayreuth: Prof. Steegborn, Department of Biochemistry,
Topic: Structural and biochemical characterization of adenylyl cyclases.

Career
from 2011 PhD student, Department of Biopolymers, Prof. Rösch, Universität Bayreuth,
Topic: Physiological and immunological characterization of PR-10 allergens.
2014 Research Internship in Science and Engineering (German Academic Exchange Service, DAAD-RISE): Supervision and project design:
Identification of natural ligands from food allergens.
2013 Inernational Symposium of Molecular Allergology (ISMA 2013): Poster presentation:
Identification of the natural ligand of Bet v 1 (poster nr.  3).
Awarded with the poster prize for outstanding presentation.
2012 Bayreuther Strukturtage, Thurnau. Oral presentation:
Solution structure of the major strawberry allergen Fra a 1.
2012 Rabensteiner Kolleg, Pottenstein. Oral presentation:
Solution structure of the major strawberry allergen Fra a 1.
2010 Internship, University of Stockholm, Prof. Mäler, Department of Biochemistry and Biophysics,
Topic: Studying the interaction of DynorphinA with the EL2 segment of the κ-opioid receptor by protein fusion.

10 Important Publications
(Members of the Dept. of Biopolymers: boldface)
[1]     Seutter von Loetzen C, Jacob T, Hartl-Spiegelhauer O, Vogel L, Schiller D, Spörlein-Güttler C, Schobert R, Vieths S, Hartl MJ, Rösch P. (2015) Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent.
PLoS One 2015; 10:e0128677
[2]     Husslik F, Hanschmann KM, Krämer A, Seutter von Loetzen C, Schweimer K, Bellinghausen I, Treudler R, Simon JC, Vogel L, Völker E, Randow S, Reuter A, Rösch P, Vieths S, Holzhauser T, Schiller D. (2015) Folded or Not? Tracking Bet v 1 Conformation in Recombinant Allergen Preparations.
PLoS One 2015; 10:e0132956
[3]     Berkner Hanna, Seutter von Loetzen Christian, Hartl Maximilian Johannes, Randow Stefanie, Gubesch Michaela, Vogel Lothar, Husslik Felix, Reuter Andreas, Lidholm Jonas, Ballmer-Weber Barbara, Vieths Stefan, Rösch Paul, & Schiller Dirk. (2014) Enlarging the Toolbox for Allergen Epitope Definition with an Allergen-Type Model Protein.
PLoS One. 2014; 9:e111691
[4]     Seutter von Loetzen Christian, Hoffmann Thomas, Hartl Maximillian Johannes, Schweimer Kristian, Schwab Wilfried, Rösch Paul, & Hartl‑Spiegelhauer Olivia. (2014) Secret of the major birch pollen allergen Bet v 1: identification of the physiological ligand.
Biochemical Journal 457: 379-390
[5]     Seutter von Loetzen Christian, Schweimer Kristian, Schwab Wilfried, Rösch Paul, & Hartl‑Spiegelhauer Olivia. (2012) Solution structure of the strawberry allergen Fra a 1.
Bioscience Reports 32: 567-575
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Research Interests
This essential question in researching allergens is: What makes a protein an allergen? In order to answer this question, I focus on the physiological and immunological characterization of allergens from the family of phathogenisis-related-10 proteins (PR-10). Millions of patients worldwide suffer from symptoms like hay-fever, atopic dermatitis or asthma caused by those allergens. Despite the clinical relevance, the physiological function as well as location of the allergen:antibody interaction of those proteins is mostly unknown. In order to identify physiological properties of PR-10 allergens, I aim to isolate and purify allergens from natural sources like pollen, fruits and vegetables using nuclear magnetic resonance (NMR) spectroscopy, high performance liquid chromatography (HPLC) and mass spectrometry. The immunological focus of this work is set on the identification of location, structure and clinical relevance of IgE-Eptitopes from PR-10 allergens. Thereby, I am using NMR-spectroscopy to analyse the interaction of the allergens with IgG or IgE.